Li-Fraumeni Syndrome

What Is Li-Fraumeni Syndrome?

The risk for breast cancer is increased with Li-Fraumeni syndrome (LFS), a genetic autosomal dominant cancer syndrome. A diagnosis of LFS is made when all of the following characteristics are present in a family:

  • Sarcoma <45 years of age and
  • A first degree relative with cancer <45 years of age and
  • A first or second degree relative with cancer <45 years of age or sarcoma at any age
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