TYPES OF CANCER IMMUNOTHERAPY

Immunotherapy encompasses several different treatment approaches, each of which has a distinct mechanism of action, and all of which are designed to boost or restore immune function in some manner.1

ANTIGEN PRESENTATION IMMUNOMODULATION

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Antigen Presentation Immunomodulation is designed to stimulate the patient’s own immune system against tumor antigens.2

By triggering the immune system, this process can initiate a durable anti-tumor response that can attack tumor cells and lead to improved survival and complete response.3-4 It is important to recognize, that Antigen Presentation Immunomodulation is far different from traditional vaccines, such as those for various infectious diseases. Most notably, the primary goal of Antigen Presentation Immunomodulation is NOT to prevent disease, but to generate an active and significant immune response against an existing cancer.5

Some Antigen Presentation Immunomodulating protocols contain a recombinant protein comprised of a tumor antigen and an immune cell activator. Once injected or infused, APCs process the antigen and then express antigenic fragments on their surface for presentation to the patient’s T cells. These activated APCs are able to interact with naïve T cells in the initiation of a T-cell driven immune response.6

Dr. Farrah Cancer Center pioneered Antigen Presentation Immunomodulation to treat over 20,000 patients with 100 different cancer types since 2001. Contact us today so that you can find what countless other patients of ours have found. A life without cancer.

MONOCLONAL ANTIBODIES

Tumor-specific monoclonal antibodies can elicit a direct or indirect immune response that leads to cell death. There are a variety of monoclonal antibodies and these work via different mechanisms of action to cause cell death.7

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Some of these mechanisms include blocking signaling pathways needed for tumor cell growth, triggering an immune-mediated cytotoxic response (eg, antigen-dependent cellular cytotoxicity), or blocking angiogenesis.7-9

Tumor-specific monoclonal antibodies have become part of the therapeutic repertoire in treating leukemia, breast, colorectal, and head and neck cancers after improving OS and progression-free survival in randomized, Phase 3 clinical trials.10-14 Response rates of 8%-10% have been observed when these are used as a single agent in advanced stage, heavily pretreated, and recurrent disease.

CHECKPOINT INHIBITORS

The immune system depends on multiple checkpoints or “immunological brakes” to avoid overactivation of the immune system on healthy cells.15-16 Tumor cells often take advantage of these checkpoints to escape detection by the immune system. CTLA-4 and PD-1 are checkpoints that have been studied as targets for cancer therapy.15-16

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CTLA-4 has been shown to be aberrantly upregulated and present on the surface of T cells in certain cancers, dampening T-cell activation in response to tumor cells.15-16 PD-1 is another immunologic checkpoint that has been found to be upregulated in certain tumors; it inhibits T-cell function contributing to the tumor’s ability to evade the immune system.15-16

Inhibiting a checkpoint (ie, “releasing the brakes”) on the immune system may enhance the anti-tumor T-cell response. This class of therapy has shown efficacy in cancer and clinical trials are ongoing.17-20

CYTOKINES

Cytokines, such as interleukin-2 (IL-2) and interferon-α (IFN-α), stimulate a broad-based immune response as opposed to generating a targeted response to a specific antigen.6,21As an example, IL-2 has numerous effects on the immune system and acts as a general T-cell growth factor.22 It does this by binding to receptors on the surface of T cells.

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This binding stimulates the proliferation of T cells, continued cytokine production, and activation of multiple types of immune cells.21 It is interesting to note that high-dose IL-2 therapy has been shown to lead to a complete response in a subset of patients with renal cell carcinoma and melanoma.21,23 This suggests that for this subset of patients, IL-2 therapy is able to successfully manipulate the endogenous anti-tumor immune response.21

immunotherapy_is_designed_to_support_immune_system_720pImmunotherapy is Adaptable (2:42)

immunotherapy_fights_cancer_720pImmunotherapy – The basics (2:32)

immunotherapy_is_tumor-specific_720pImmunotherapy is Tumor-Specific (2:03)

patient-immunotherapyImmunotherapy Cancer a guide for patients (3:26)

immunotherapy_empowers_a_durable_immune_response_720pImmunotherapy Empowers a Durable Immune Response (2:19)

real-video-cytotoxic-t-cells-killing-cervical-cancer-cellsCytotoxic cells killing cervical cancer cells (0:32)

real-video-killer-t-cell-destroying-cancerKiller T-cell Destroying Cancer (1:10)

real-video-natural-killer-t-cellNatural killer T cell
(0:54)

real-video-natural-killer-cell-attacking-a-tumor-cellNatural Killer Cell Attacking a Tumor Cell (0:47)

immunotherapy_commercialImmunotherapy Commercial (0:57)

immunotherapy-creates-cancer-killing-ninjasImmunotherapy Creates Cancer Killing Ninjas (1:28)

immunotherapy-is-now-promoted-by-mskccImmunotherapy is now promoted by MSKCC (1:19)

immunotherapy-how-the-immune-system-sees-and-destroys-tumorsHow the immune system sees and destroys tumors (28:35)

real-video-nk-cells-killing-cancer-cellsREAL VIDEO NK cells killing cancer cells (0:20)

terminatorTerminator NK Cells (0:51)

immunotherapy-is-now-promoted-by-uclaImmunotherapy is now promoted by UCLA (3:12)

real-video-killer-t-cell_the-cancer-assassinKiller T Cell The Cancer Assassin (1:58)

immunotherapy-awareness-monthImmunotherapy Awareness Month (0:46)

immunotherapy-our-immune-system-immune-response-high-qualityOur Immune System Inflammatory Response (4:45)

immunotherapy-animated-explanationImmunotherapy Animated Explanation (3:02)

real-video-natural-killer-cell-01Natural Killer Cell 01
(0:25)

immunotherapy-now-promoted-by-johns-hopkinsImmunotherapy Now Promoted By Johns Hopkins (3:59)

immunology-in-the-gut-mucosaImmunology of the Gut Mucosa (5:56)

REFERENCES

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